Listando por materia "Bioinformàtica"
Mostrando ítems 1-20 de 21
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Anàlisi de les interfícies d’interacció en homòmers de receptors acoblat a proteïna G
(2017-06)Els receptors acoblats a proteïna G (GPCRs en l’acrònim en anglès) formen la família més gran de proteïnes de membrana. Estan involucrats en importants funcions fisiològiques i constitueixen dianes ... -
Association between polymorphic inversions and miRNA in cancer data
(2016-09)Inversion polymorphisms is a mechanism that involves a change in the orientation of a DNA segment within a chromosome, but there is still a lack of their association with disease. However, recently ... -
Bioinformatic tools for Big Data in Omic studies with application to genomic inversion calling and multiomic data integration
(2020-09)Motivation: The diversity and huge omics data take biology and biomedicine research and application into a big data era. Most of the current statistical analyses required to analyze omic data are not ... -
Bioinformatics Pipeline for Next Generation Sequencing Analysis in Association Studies of Idiopathic Pulmonary Fibrosis
(2015-09)A complete bioinformatics pipeline for Next Generation Sequencing (NGS) analysis has been developed and applied to study the association of called variants with susceptibility in Idiopathic Pulmonary ... -
Bioinformatics tools for membrane proteins: from sequences to structure and function
(2022-02-09)Membrane proteins are a large group of proteins that play an essential role in the cell. This group includes receptors, ion channels, transporters, and enzymes, which account for 25% of the proteins in ... -
Development of a machine learning algorithm classification tool to improve strain detection in whole genome metagenomics dataset
(2020-05-15)Metagenomics is a pioneering branch of bioinformatics that utilizes genomics techniques, like the sequencing of the DNA, in order to obtain important information about microorganisms. During the recent ... -
An efficient algorithm to perform multiple testing in epistasis screening
(2013)Background: Research in epistasis or gene-gene interaction detection for human complex traits has grown over the last few years. It has been marked by promising methodological developments, improved ... -
Evolution of mtDNA variation during canid’s domestication
(2017-09-18)The close coexistence between human beings and dogs and the efficiency in their domestication have made dogs a very interesting target for basic research. By studying the history and evolution of dogs, ... -
FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals
(2010-04)We propose a novel multifactor dimensionality reduction method for epistasis detection in small or extended pedigrees, FAM-MDR. It combines features of the Genome-wide Rapid Association using Mixed ... -
Integration of omics and non-omics data in pancreatic cancer research
(2018-09-17)Background: With the wide-spreading in high-throughput technologies and the arrival of omics era, new bioinformatics tools are available for the integration of different data types. Epidemiological and ... -
MB-MDR: Model-Based Multifactor Dimensionality Reduction for detecting interactions in high-dimensional genomic data
(2008-02-05)L’anàlisi de l’efecte dels gens i els factors ambientals en el desenvolupament de malalties complexes és un gran repte estadístic i computacional. Entre les diverses metodologies de mineria de dades que ... -
mbmdr: an R package for exploring gene–gene interactions associated with binary or quantitative traits
(2010)Summary: We describe mbmdr, an R package for implementing the model-based multifactor dimensionality reduction (MB-MDR) method. MB-MDR has been proposed by Calle et al. as a dimension reduction method ... -
Metabolic state prediction at Single-cell resolution
(2024-06)La diversitat en el metabolisme condueix a poder observar diferents caracteristiques cel・lulars dins un mateix teixit. Aquest concepte, anomenat heterogeneitat tissular, es fonamental en els sistemes ... -
Metodologies d’anàlisi del microbioma amb R
(2021-06)El microbioma és una comunitat microbiana característica que ocupa un hàbitat ben definit, amb unes propietats fisico-químiques determinades i té un paper clau en la salut i/o el correcte funcionament ... -
Model-Based Multifactor Dimensionality Reduction for detecting epistasis in case–control data in the presence of noise
(2011)Analyzing the combined effects of genes and/or environmental factors on the development of complex diseases is a great challenge from both the statistical and computational perspective, even using a ... -
Novel transcript discovery in yeast using sequencing reads from Oxford Nanopore Technologies in comparison to Next Generation Sequencing
(2018-09)The advent of Oxford Nanopore Technologies is expected to play a pivotal role in near future sequencing studies. Omics data analysis and related processes, currently bound to Next Generation Sequencing, ... -
Prediction and punctuation of the effect of non-synonymous single nucleotide polymorphisms of the structure and function of membrane proteins
(2016-09)In recent years many SNPs have been identified, some of these linked to certain diseases and other with unknown effects. Different web servers have been developed to classify SNP in pathological or not ... -
Refining and improving a next-generation sequencing gene panel for clinical diagnosis of hereditary hematologic diseases and development of bioinformatic tools for biomedical analysis
(2019-11-12)En este doctorado industrial, el objetivo era cumplir los objetivos innovadores de Whole Genix, que incluyen: dominar los protocolos de secuenciación masiva de próxima generación (en inglés next-generation ... -
Rna sequencing role in the genetic diagnosis of hereditary breast and ovarian cancer
(2024-09-10)Hereditary breast and ovarian cancer (HBOC) is a syndrome defined by an increased risk of developing breast cancer (BC) and/or ovarian cancer (OC), mainly due to germline pathogenic variants in BRCA1 ... -
Skewed expression and up-regulation of the IL-12 and IL-18 receptors in resting and activated CD4 T cells from HIV-1-infected patients
(2007)IL-12 and IL-18 synergistically induce the production of IFN- by resting and activated T cells. To evaluate whether this induction was affected in HIV-1-infected patients, PBMC or isolated CD4 T ...