Repositori institucional de la UVic-UCC
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Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer
(International Journal of Molecular Sciences, 2023)Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to ... -
Proteasomal-mediated degradation of AKAP150 accompanies AMPAR endocytosis during cLTD
(eNeuro, 2020)The number and function of synaptic AMPA receptors (AMPARs) tightly regulates excitatory synaptic transmission. Current evidence suggests that AMPARs are inserted into the postsynaptic membrane during ... -
To be or not to be a fat burner, that is the question for cpt1c in cancer cells
(Cell Death & Disease, 2023)There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis, prognosis, and treatment of different tumor types. Described as a prognostic marker for many tumors is the neuronal ... -
International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes
(Pharmacological Reviews, 7(3), 1-47, 2025-05)The carnitine palmitoyltransferases (CPTs) play a key role in controlling the oxidation of long-chain fatty acids and are potential therapeutic targets for diseases with a strong metabolic component, ... -
The return of malonyl-CoA to the brain: Cognition and other stories
(Progress in Lipid Research, 81, 1-11, 2021-01)Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracellular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty acid ...