Browsing by Subject "ADN"
Now showing items 1-20 of 20
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Association between polymorphic inversions and miRNA in cancer data
(2016-09)Inversion polymorphisms is a mechanism that involves a change in the orientation of a DNA segment within a chromosome, but there is still a lack of their association with disease. However, recently ... -
Clopidogrel Pharmacogenetics, resistance to antiplatelet therapy in ischemic stroke by Epigenome Wide Association Study (EWAS).
(2014-03)Clopidogrel is a widely used antiplatelet drug used in preventing vascular events after suffering a first stoke. Genome-wide association studies (GWAS) has not been able to establish a clear association ... -
Combinatorial strain engineering in Pichia pastoris using Golden Gate cloning
(2014-09)this final project, we show the results of a strain engineering strategy for heterologous protein production in the host organism Pichia pastoris. P. pastoris is a yeast with a huge industrial potential ... -
Combined biostatistics and bioinformatics analyses to identify epigenetically regulated host factors associated with control of HIV disease progression
(2015-09)A small, but considerable proportion (1-3%) of HIV infected individuals can control their infection in the absence of antiretroviral treatment (ART), while others progress to Acquired Immune-Deficiency ... -
Comparative analysis of Microarray and RNAseq data from liver cancer samples
(2017-07-17)Background: The field of transcriptomics has developed an exponential growth in the last years thanks to the advances in high throughput RNA sequencing (RNAseq), which is becoming more popular as the ... -
Edició genòmica mitjançant la tècnica CRISPR-Cas per l’estudi de la síndrome de Rett
(2018-01)El sistema CRISPR-Cas és un mecanisme de defensa utilitzat per alguns bacteris per eliminar virus o plàsmids invasius. Està format per una proteïna anomenada Cas, la qual té activitat nucleasa i s’encarrega ... -
Epigenetic Clock Assessment
(2017-09-18)Background: During the last decade, multiple efforts have been dedicated to the modelling of an accurate predictor of age based on DNA methylation status(1–4). However, most of current models have been ... -
Epigenomic data integration for characterization of promoter regions
(2016-09-19)Understanding the regulatory machinery is one of the current challenges for research in cancer epigenomics. Regulation of gene expression is a complex process with many components involved in it such ... -
Estudi de les tècniques de diagnòstic prenatal a partir de l'àcid desoxiribonucleic lliure a la sang materna i avaluació de la seva implantació al sistema sanitari espanyola
(2020-06)Introducció: Des del seu descobriment l’any 2011, les proves de detecció amb ADN lliure per alteracions fetals genètiques han sigut una molt bona alternativa als mètodes tradicionals. Aquest treball fa ... -
Finding and characterizing Partially Methylated Domains in human haematopoietic cells
(2014-09)DNA cytosine methylation has been demonstrated to be a central epigenetic modification that has essential roles in a myriad of cellular processes. Some examples of these include gene regulation, DNA-protein ... -
Generation of a cellular model, based on CaCO2 cells, to study tight junction's formation and dynamics. CRISPR/Cas mediated gene edition to fluorescently tag the occludin protein
(2020-06)Tight junctions are present in all epithelial tissues and are involved in several processes of signalling and barrier formation. Although the proteins that compose them are known, some of the exact ... -
Genomas y proteomas
(2000)Una lección como la que hoy tengo el placer de leer con motivo del acto inaugural del curso 2000-2001 tiene que tener forzosamente unas características algo diferentes de las lecciones que impartimos ... -
Genome-wide DNA methylation association study of predominant breastfeeding
(2016-09-19)Introduction: Breastfeeding is considered a healthy habit with clear benefits at population level. It has been associated with lower risk of infections, asthma, obesity, diabetes or malocclusion, with ... -
Genomes i proteomes
(2000)Una lliçó com la que avui tinc el gust de llegir amb motiu de l'acte inaugural del curs 2000-2001 ha de tenir forçosament unes característiques una mica diferents de les lliçons que impartim al llarg ... -
Identificació i estudi filogenètic d’espècies properes mitjançant la tècnica de DNA Barcoding
(2019-06)La identificació taxonòmica d’espècies properes requereix en ocasions la intervenció d’un taxònom expert en el grup zoològic en qüestió, i sovint hi ha de dedicar un esforç important. Actualment, s’han ... -
Local assortativity as a chromatin network analysis tool
(2018-09)Using network analysis in the study of chromatin 3D structure has proved to be a powerful and useful approach. In order to determine which factors bound to DNA might play a role in establishing these ... -
Methylation Data Analysis Associated with Alzheimer’s Disease
(2015-09)Alzheimer disease (AD) is associated with distinctive changes in DNA methylation patterns. DNA methylation is a chemical modification that is involved in gene silencing. These modifications give rise ... -
MicroRNA Profile in CD8+ T-Lymphocytes from HIV-Infected Individuals: Relationship with Antiviral Immune Response and Disease Progression
(2016)Background The relationship between host microRNAs (miRNA), viral control and immune response has not yet been elucidated in the field of HIV. The aim of this study was to assess the differential miRNA ... -
Millora del procés d'anàlisi de seqüències de DNA barcodings i el seu estudi taxonòmic
(2020-06)El DNA barcoding és un sistema d’identificació d’organismes que serveix com a complement de l’anàlisi morfològic per classificar els espècimens més acuradament i per l’elaboració d’estudis evolutius. ...