Browsing by Subject "Càncer -- Aspectes genètics"
Now showing items 1-10 of 10
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Genetic Variation in the TP53 Pathway and Bladder Cancer Risk. A Comprehensive Analysis
(2014)Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. ... -
Human proteome-wide characterization of highly mutated regions presented by HLA class I
(2024-09-10)Tumor evolution is influenced by the interaction between cancer cells and the patient’s adaptive immune system, which shapes the tumor growth and the landscape of observed somatic variants. However, ... -
IKBα and Cancer
(2013-10-01)It has been previously described that although phosphorylation of S32,36 is the instructive mark that targets IKBα for K21,22 ubiquitination and its subsequent degradation by the proteasome, ... -
Insights into the transcriptomic effects of olaparib response on a breast cancer preclinical model
(2022-09)In the past decades, many breast cancer treatments have been approved. Although an effort has been done to identify sensitive patients to specific treatments, such as targeted therapies like ... -
Machine learning-based gene expression signature for classification of endocrine therapy sensitivity in ER+ breast cancer patients
(2023-09-10)Abstract: Endocrine therapy (ET) combined with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) is the standard treatment for metastatic estrogen receptor-positive (ER+) breast cancer. However, not all ... -
Refining the genomic landscape of pediatric and young adult aggressive B-cell lymphomas
(2022-09-12)Aggressive B-cell non-Hodgkin lymphomas in children and young adults (CAYA) include the genetically well-defined Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). Additionally, a group ... -
Susceptibilitat genètica al càncer gàstric: caracterització de les interaccions de segon ordre entre gens i variants identificades en l’estudi EPIC‐EURGAST
(2013-06-18)En aquest Treball de Final de Grau s’exposen els resultats de l’anàlisi de les dades genètiques del projecte EurGast2 "Genetic susceptibility, environmental exposure and gastric cancer risk in an ... -
The effect of BRD4-NUT fusion on replication stress status of the NUT carcinoma
(2022-06)El carcinoma NUT (NC) és un tipus de càncer humà rar i molt agressiu provocat per reordenacions genòmiques, que resulten en fusions entre el gen específic de testicles NUT i gens codificants per reguladors ... -
Transcriptomic analysis of BRCA1 and BRCA2 carriers
(2023-09-01)Most frequently mutations that lead to the development of breast and ovarian cancer are BRCA1 and BRCA2. Blood samples from BRCA1, BRCA2 and non-mutation carriers were extracted for both healthy and ...