Visualitzant per matèria "Epidemiologia genètica"
Ara mostrant els elements 1-7 de 7
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An efficient algorithm to perform multiple testing in epistasis screening
(2013)Background: Research in epistasis or gene-gene interaction detection for human complex traits has grown over the last few years. It has been marked by promising methodological developments, improved ... -
FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals
(2010-04)We propose a novel multifactor dimensionality reduction method for epistasis detection in small or extended pedigrees, FAM-MDR. It combines features of the Genome-wide Rapid Association using Mixed ... -
Improving strategies for detecting genetic patterns of disease susceptibility in association studies
(2008)The analysis of gene interactions and epistatic patterns of susceptibility is especially important for investigating complex diseases such as cancer characterized by the joint action of several genes. ... -
MB-MDR: Model-Based Multifactor Dimensionality Reduction for detecting interactions in high-dimensional genomic data
(2008-02-05)L’anàlisi de l’efecte dels gens i els factors ambientals en el desenvolupament de malalties complexes és un gran repte estadístic i computacional. Entre les diverses metodologies de mineria de dades que ... -
mbmdr: an R package for exploring gene–gene interactions associated with binary or quantitative traits
(2010)Summary: We describe mbmdr, an R package for implementing the model-based multifactor dimensionality reduction (MB-MDR) method. MB-MDR has been proposed by Calle et al. as a dimension reduction method ... -
Model-Based Multifactor Dimensionality Reduction for detecting epistasis in case–control data in the presence of noise
(2011)Analyzing the combined effects of genes and/or environmental factors on the development of complex diseases is a great challenge from both the statistical and computational perspective, even using a ... -
Proposal, evaluation and application of two new methodologies for genetic profiling in association studies
(2015-04-22)L'objectiu de l'epidemiologia genètica és comprendre els efectes dels gens i els factors ambientals en la salut humana. Un aspecte important és l’estudi del paper de la variabilitat genètica en el risc ...