Listando por materia "VIH (Virus)"
Mostrando ítems 1-20 de 26
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A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
(2015)Background: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been ... -
A phase I randomized therapeutic MVA-B vaccination improves the magnitude and quality of the T cell immune responses in HIV-1-infected subjects on HAART
(2015)Trial Design Previous studies suggested that poxvirus-based vaccines might be instrumental in the therapeutic HIV field. A phase I clinical trial was conducted in HIV-1-infected patients on highly active ... -
Antiviral activity and CSF concentrations of 600/100 mg of darunavir/ritonavir once daily in HIV-1 patients with plasma viral suppression
(2015)Objectives: The objective of this study was to assess whether a lower dose than the currently used one of darunavir/ ritonavir might achieve good CSF concentrations and contribute to inhibition of CNS ... -
Combined biostatistics and bioinformatics analyses to identify epigenetically regulated host factors associated with control of HIV disease progression
(2015-09)A small, but considerable proportion (1-3%) of HIV infected individuals can control their infection in the absence of antiretroviral treatment (ART), while others progress to Acquired Immune-Deficiency ... -
Comparison of two different strategies of treatment with zoledronate in HIV-infected patients with low bone mineral density: single dose versus two doses in 2 years
(2015)Objectives Given the need for easily managed treatment of osteoporosis in HIV-infected patients, we evaluated the efficacy and tolerability of two doses of zoledronate, by comparing three groups of ... -
Detection of HIV-1-specific T-cell immune responses in highly HIV-exposed uninfected individuals by in-vitro dendritic cell co-culture
(2015)Background: Although virus-specific responses are rarely detected by conventional approaches, we report here the detection of T-cell responses in HIV-exposed seronegative (HESN) patients by two distinct ... -
Determinants of virological failure and antiretroviral drug resistance in Mozambique
(2015)Objectives: The objective of this study was to inform public health actions to limit first-line ART failure and HIV drug resistance in Mozambique. Methods: This was a cross-sectional study. HIV-1-infected ... -
Establishment and replenishment of the viral reservoir in perinatally HIV-1-infected children initiating very early antiretroviral therapy
(2015)Background. Combination antiretroviral therapy (cART) generally suppresses the replication of the human immunodeficiency virus type 1 (HIV-1) but does not cure the infection, because proviruses persist ... -
Exploring HLA class II allele associations with markers of HIV control
(2016-09-19)Among HIV seropositive individuals, the progression of the HIV-related disease is quite heterogeneous, partially due to the genetic background of the patients. Different host genetic factors have been ... -
Gp120/CD4 blocking antibodies are frequently elicited in ART-naïve chronically HIV-1 infected individuals
(2015)Antibodies with the ability to block the interaction of HIV-1 envelope glycoprotein (Env) gp120 with CD4, including those overlapping the CD4 binding site (CD4bs antibodies), can protect from infection ... -
HIV-1 immune activation induces siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
(2015)Background: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis ... -
Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1
(2015)Cytotoxic-T lymphocyte (CTL) responses to epitopes in alternative HIV reading frames have been reported. However, the extent of CTL responses to putative proteins encoded in antisense reading frames is ... -
Interferon-stimulated gene expression in HIV-1 inoculated macrophages and healthy Langerhans cells: The impact of macrophage polarization and Langerhans cell maturation
(2024-09-30)Abstract Background: Antigen presenting cells (APCs) have been extensively studied for their role in human immunodeficiency virus type 1 (HIV-1) infection. HIV-1 is readily recognized by APCs, which ... -
Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized ultrasensitive 454 pyrosequencing
(2015)Objectives: It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART. Methods: This Europe-wide case–control ... -
Perfil de resistencias y barrera genética de dolutegravir
(2015)Dolutegravir tiene un perfil de resistencias significativamente distinto al de anteriores inhibidores de la integrasa. Es activo in vitro frente a VIH-1 (virus de la inmunodeficiencia humana-1) portador ... -
Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
(2017)Objective To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design Nested case-control study ... -
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif
(2017)The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity ... -
Reduced darunavir dose is as effective in maintaining HIV suppression as the standard dose in virologically suppressed HIV-infected patients: a randomized clinical trial
(2015)Objectives: Maximizing ART efficiency is of growing interest. This study assessed the efficacy, safety, pharmacokinetics and economics of a darunavir dose-reduction strategy. Methods: This was a ... -
Risk of HIV infection as a function of the duration of intravenous drug use: a non-parametric Bayesian approach
(2000)We analyse the elapsed time between intravenous (IV) drug initiation and HIV infection in a cohort of 972 injecting drug users attending a hospital detoxi cation unit. We use the time of seroconversion ...