Articles, congressos, llibres: Envíos recientes
Mostrando ítems 461-480 de 1874
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Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial
(2018)IMPORTANCE Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some ... -
Binimetinib Encorafenib and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study
(2019)To determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E-mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, ... -
Phase II Study of the Dual EGFR/HER3 Inhibitor Duligotuzumab (MEHD7945A) versus Cetuximab in Combination with FOLFIRI in Second-Line RAS Wild-Type Metastatic Colorectal Cancer
(2018)Purpose: Duligotuzumab is a dual-action antibody directed against EGFR and HER3. Experimental Design: Metastatic colorectal cancer (mCRC) patients with KRAS ex2 wild-type received duligotuzumab or ... -
Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer
(2019)Colorectal cancers with BRAF mutations have an aggressive natural history and are often resistant to therapy. A treatment regimen that combined BRAF inhibition, MET inhibition, and blocking of EGFR ... -
Multicenter Phase I Study of Erdafitinib (JNJ-42756493) Oral Pan-Fibroblast Growth Factor Receptor Inhibitor in Patients with Advanced or Refractory Solid Tumors
(2019)Purpose: Here, we report results of the first phase I study of erdafitinib, a potent, oral pan-FGFR inhibitor. Patients and Methods: Patients age >= 18 years with advanced solid tumors for which ... -
Efficacy and Safety of Pembrolizumab or Pembrolizumab plus Chemotherapy vs Chemotherapy Alone for Patients with First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial
(2020)IMPORTANCE Safe and effective therapies for untreated, advanced gastric/gastroesophageal junction (G/GEJ) cancer remain an unmet need. OBJECTIVE To evaluate the antitumor activity of pembrolizumab, ... -
Encorafenib plus cetuximab as a new standard of care for previously treated BRAF V600E-mutant metastatic colorectal cancer: Updated survival results and subgroup analyses from the BEACON study
(2021)PURPOSE BEACON CRC evaluated encorafenib plus cetuximab with or without binimetinib versus investigators' choice of irinotecan or FOLFIRI plus cetuximab in patients with BRAF V600E-mutant metastatic ... -
Intellectual Disability, Autism Spectrum Disorders, Psychiatric Comorbidities and Their Relationship with Challenging Behavior
(2022)Background The purpose of this study was to assess the prevalence of unknown comorbid mental disorders in individuals with mild/moderate intellectual disability (ID) with/without autism spectrum disorders ... -
Metabolic impact of a nutrition education program for the promotion of fruit and vegetable consumption with people with severe mental disorders (DIETMENT)
(2022)Objectives The aim of this study is to determine the metabolic impact of a nutrition education program on metabolic parameters and the presence of metabolic syndrome (MetS). Results Seventy-four patients ... -
Factors that influence the implementation of "sit less, move more" interventions in an outpatient mental health care setting
(2022)Introduction: Few interventions in outpatient mental health care settings focus on tackling excessive sedentary behaviour in patients with severe mental illness (SMI). In order to develop effective ... -
Underdiagnosis of psychiatric disorders in people with intellectual disabilities: Differences between psychiatric disorders and challenging behaviour
(2020)The purpose of this study was to assess the level of mental disorders and challenging behaviour in individuals with intellectual disability (ID) supported by specialized services, but without a prior ... -
Theory of Mind in Euthymic Bipolar Patients and First-Degree Relatives
(2017)The present study analyzed the capacity for mentalization of patients with bipolar disorder (BD) and their first-degree relatives (FDR) and examined the implications of clinical variables and cognitive ... -
Análisis de la cohesión y la conducta percibida en jugadores profesionales de balonamno
(2023)El objetivo del presente estudio fue analizar la correlación entre las conductas del liderazgo percibido del Modelo Multidimensional de Liderazgo (MML) y las categorías de cohesión del Modelo de Cohesión ... -
Análisis de las conductas de liderazgo en jugadores profesionales de balonmano. Analysis of leadership behaviours in professional handball players
(2022)The aim of this study was to analyse the differences between the self perceptions of preferred and perceived leadership behaviours in high performance handball players at two different moments of the ... -
Independent podcast networks in Spain: A grassroots cultural production facing cultural industry practices
(2023)This article analyses the main Spanish independent podcast networks. It is a two-phase qualitative study based on direct observation of the networks, a number of secondary sources and, especially, on ... -
Podium Podcast and the freedom of podcasting: Beyond the limits of radio programming and production constraints
(2019)The evolution of the Internet and the impact of digitalization have led the radio industry to try new production, distribution and commercialization strategies. In Spain, radio on the Internet began in ... -
Del flujo al stock: el programador radiofónico ante la gestión del catálogo digital
(2019)Más allá del indudable resurgir del podcast, su presencia en la oferta de algunas emisoras españolas merece un análisis detallado. Este estudio presenta el estudio de dicha oferta, así como una ...