Hydrogels Associated with Photodynamic Therapy Have Antimicrobial Effect against Staphylococcus aureus: A Systematic Review
Visualitza/Obre
Autor/a
Altres autors/es
Data de publicació
2024ISSN
2310-2861
Resum
Staphylococcus aureus (S. aureus) is a Gram-positive bacterium that causes infections ranging
from mild superficial cases to more severe, potentially fatal conditions. Many photosensitisers used in
photodynamic therapy are more effective against superficial infections due to limitations in treating
deeper tissue infections. Recently, attention to this bacterium has increased due to the emergence of
multidrug-resistant strains, which complicate antibiotic treatment. As a result, alternative therapies,
such as antimicrobial photodynamic therapy (PDT), have emerged as promising options for treating
non-systemic infections. PDT combines a photosensitiser (PS) with light and oxygen to generate
free radicals that destroy bacterial structures. This systematic review evaluates the effectiveness of
PDT delivered via different types of hydrogels in treating wounds, burns, and contamination by
S. aureus. Following PRISMA 2020 guidelines, a bibliographic search was conducted in PubMed, Web
of Science, and Scopus databases, including articles published in English between 2013 and 2024.
Seven relevant studies were included, demonstrating evidence of PDT use against S. aureus in in vitro
and in vivo studies. We concluded that PDT can effectively complement antimicrobial therapy in the
healing of wounds and burns. The effectiveness of this technique depends on the PS used, the type of
hydrogel, and the lesion location. However, further in vivo studies are needed to confirm the safety
and efficacy of PDT delivered via hydrogels.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
61 - Medicina
Paraules clau
Pàgines
19 p.
Publicat per
MDPI
Citació
Moura, R.S.; Afonso, J.P.R.; Mello, D.A.C.P.G.; Palma, R.K.; Oliveira-Silva, I.; Oliveira, R.F.; Oliveira, D.A.A.P.; Santos, D.B.; Silva, C.H.M.; Guedes, O.A.; et al. Hydrogels Associated with Photodynamic Therapy Have Antimicrobial Effect against Staphylococcus aureus: A Systematic Review. Gels 2024, 10, 635. https:// doi.org/10.3390/gels10100635
Nota
Systematic Review
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Articles [1531]
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by/4.0/