Recent Submissions
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Pig slurry fertilization in a double-annual cropping forage system under sub-humid mediterranean conditions
(2016)In areas of Southern Europe with very intensive pig production, most of the pig slurry (PS) is applied asfertilizer. However, in the European Union, no more than 170 kg N ha−1year−1can be applied in ... -
The Spanish Civil War as seen through children’s drawings of the time
(2015)This article presents the most significant results to have emerged from the research process “Documentation, interpretation and digital diffusion of the educational patrimony produced in the period ... -
Global adaptive rank truncated product method for gene-set analysis in association studies
(2014)Gene set analysis (GSA) aims to assess the overall association of a set of genetic variants with a phenotype and has the potential to detect subtle effects of variants in a gene or a pathway that might ... -
Model-Based Multifactor Dimensionality Reduction for detecting epistasis in case–control data in the presence of noise
(2011)Analyzing the combined effects of genes and/or environmental factors on the development of complex diseases is a great challenge from both the statistical and computational perspective, even using a ... -
mbmdr: an R package for exploring gene–gene interactions associated with binary or quantitative traits
(2010)Summary: We describe mbmdr, an R package for implementing the model-based multifactor dimensionality reduction (MB-MDR) method. MB-MDR has been proposed by Calle et al. as a dimension reduction method ... -
AUC-RF: A New Strategy for Genomic Profiling with Random Forest
(2011)Objective: Genomic profiling, the use of genetic variants at multiple loci simultaneously for the prediction of disease risk, requires the selection of a set of genetic variants that best predicts ... -
A dynamic model for the risk of bladder cancer progression
(2012)We propose a multistate modeling approach to describe the observed evolution of patients diagnosed with nonmuscle- invasive bladder cancer. On the basis of data from the Spanish Bladder Cancer/EPICURO ... -
Application of Multi-SNP Approaches Bayesian LASSO and AUC-RF to Detect Main Effects of Inflammatory-Gene Variants Associated with Bladder Cancer Risk
(2013)The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder ... -
An efficient algorithm to perform multiple testing in epistasis screening
(2013)Background: Research in epistasis or gene-gene interaction detection for human complex traits has grown over the last few years. It has been marked by promising methodological developments, improved ...