Repositori institucional de la UVic-UCC: Enviaments recents
Ara mostrant els elements 1461-1480 de 7070
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Host epigenetic changes to Salmonella Paratyphi exposure
(2023-09-10)Motivation: Typhoid fever, resulting from Salmonella enterica serovars Typhi and Paratyphi A, stands as a significant contributor to illness and mortality. Recent challenge studies on the host immunity ... -
Doing, being and verbalizing: Narratives of queer migrants from Muslim backgrounds in Spain
(2021)The hegemonic narrative in the West establishes that having same-sex relationships constitutes an identity that must be public. This article analyses how this narrative is reproduced and/or subverted ... -
Unveiling distinct features of long-term benefit in metastatic NSCLC patients undergoing immune checkpoint blockade
(2023-09-01)Introduction: Immunotherapy is firmly established as a treatment regimen in various solid tumors, driven by its exceptional benefits observed in a select group of patients. Despite widespread use of ... -
Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial
(2018)IMPORTANCE Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some ... -
Transcriptomic analysis of BRCA1 and BRCA2 carriers
(2023-09-01)Most frequently mutations that lead to the development of breast and ovarian cancer are BRCA1 and BRCA2. Blood samples from BRCA1, BRCA2 and non-mutation carriers were extracted for both healthy and ... -
Lipid metabolism as a therapeutic vulnerability in medulloblastoma
(2023-09-01)Medulloblastoma (MB) is the most common malignant brain tumor in children and presents a varied prognosis, with some patients succumbing to the disease and survivors presenting neurotoxic sequelae from ... -
Binimetinib Encorafenib and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study
(2019)To determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E-mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, ... -
Phase II Study of the Dual EGFR/HER3 Inhibitor Duligotuzumab (MEHD7945A) versus Cetuximab in Combination with FOLFIRI in Second-Line RAS Wild-Type Metastatic Colorectal Cancer
(2018)Purpose: Duligotuzumab is a dual-action antibody directed against EGFR and HER3. Experimental Design: Metastatic colorectal cancer (mCRC) patients with KRAS ex2 wild-type received duligotuzumab or ... -
Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer
(2019)Colorectal cancers with BRAF mutations have an aggressive natural history and are often resistant to therapy. A treatment regimen that combined BRAF inhibition, MET inhibition, and blocking of EGFR ... -
Multicenter Phase I Study of Erdafitinib (JNJ-42756493) Oral Pan-Fibroblast Growth Factor Receptor Inhibitor in Patients with Advanced or Refractory Solid Tumors
(2019)Purpose: Here, we report results of the first phase I study of erdafitinib, a potent, oral pan-FGFR inhibitor. Patients and Methods: Patients age >= 18 years with advanced solid tumors for which ... -
Efficacy and Safety of Pembrolizumab or Pembrolizumab plus Chemotherapy vs Chemotherapy Alone for Patients with First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial
(2020)IMPORTANCE Safe and effective therapies for untreated, advanced gastric/gastroesophageal junction (G/GEJ) cancer remain an unmet need. OBJECTIVE To evaluate the antitumor activity of pembrolizumab, ... -
Encorafenib plus cetuximab as a new standard of care for previously treated BRAF V600E-mutant metastatic colorectal cancer: Updated survival results and subgroup analyses from the BEACON study
(2021)PURPOSE BEACON CRC evaluated encorafenib plus cetuximab with or without binimetinib versus investigators' choice of irinotecan or FOLFIRI plus cetuximab in patients with BRAF V600E-mutant metastatic ... -
HRAS physical feature analysis: Predicting protein activation through a random forest classifier
(2023-09-10)Over the past decade, increased computational capabilities have enabled us to address biological questions using data-driven methods, particularly where traditional techniques have been limiting. We ... -
A CITE-seq analytical pipeline for the identification and molecular characterisation of dual targeting CAR T-cell products
(2023-09-01)The clinical application of T-cells genetically engineered to express a chimeric antigen receptor (CAR) targeting CD19 is challenged by CD19 negative relapse in B-cell acute lymphoblastic leukaemia (B-ALL). ... -
Intellectual Disability, Autism Spectrum Disorders, Psychiatric Comorbidities and Their Relationship with Challenging Behavior
(2022)Background The purpose of this study was to assess the prevalence of unknown comorbid mental disorders in individuals with mild/moderate intellectual disability (ID) with/without autism spectrum disorders ... -
Metabolic impact of a nutrition education program for the promotion of fruit and vegetable consumption with people with severe mental disorders (DIETMENT)
(2022)Objectives The aim of this study is to determine the metabolic impact of a nutrition education program on metabolic parameters and the presence of metabolic syndrome (MetS). Results Seventy-four patients ... -
Factors that influence the implementation of "sit less, move more" interventions in an outpatient mental health care setting
(2022)Introduction: Few interventions in outpatient mental health care settings focus on tackling excessive sedentary behaviour in patients with severe mental illness (SMI). In order to develop effective ... -
Underdiagnosis of psychiatric disorders in people with intellectual disabilities: Differences between psychiatric disorders and challenging behaviour
(2020)The purpose of this study was to assess the level of mental disorders and challenging behaviour in individuals with intellectual disability (ID) supported by specialized services, but without a prior ... -
Theory of Mind in Euthymic Bipolar Patients and First-Degree Relatives
(2017)The present study analyzed the capacity for mentalization of patients with bipolar disorder (BD) and their first-degree relatives (FDR) and examined the implications of clinical variables and cognitive ...