Listando Màster Universitari en Anàlisi de Dades Òmiques por título
Mostrando ítems 1-20 de 89
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A CITE-seq analytical pipeline for the identification and molecular characterisation of dual targeting CAR T-cell products
(2023-09-01)The clinical application of T-cells genetically engineered to express a chimeric antigen receptor (CAR) targeting CD19 is challenged by CD19 negative relapse in B-cell acute lymphoblastic leukaemia (B-ALL). ... -
A pilot study on extracellular vesicles (EV)s and their small RNA (sRNA) expression pattern in Huntington's Disease progression
(2021-09-15)The characterization of the small transcriptome reveals a generalized down-regulation both at premanifest and manifest stages, which brings out the course of Huntington’s disease. Partial Least Squares ... -
A population genomic analysis of genetic markers associated to Twinning susceptibility in humans
(2018-09-17)Spontaneous dizygotic (DZ) twinning is a complex trait with an important contribution from environmental factors and genetic disposition. Twin births is a common event with a worldwide incidence that ... -
An evaluation of automated methods for cell type annotation in scRNA-seq data
(2022-09)Single-cell RNA sequencing (scRNA-seq) is a powerful new method that makes it possible to study gene expression data at the level of individual cells. Cell type annotation, using a reference sets, is ... -
An unsupervised multi-omics clustering based on ensemble deep learning reveals subgroups of cancer patients
(2021-09)ancer is a complex disease caused by the abnormal behavior and interaction of different bio entities (e.g., genes, proteins and epigenetic factors), which are profiled using omics technologies (e.g., ... -
Analysis of the mitochondrial DNA of Schizophrenia patients by next generation sequencing
(2014-01)Mitochondrial DNA (mtDNA), a maternally inherited 16.6-Kb molecule crucial for energy production, is implicated in numerous human traits and disorders. It has been hypothesized that the ... -
Association between polymorphic inversions and miRNA in cancer data
(2016-09)Inversion polymorphisms is a mechanism that involves a change in the orientation of a DNA segment within a chromosome, but there is still a lack of their association with disease. However, recently ... -
Benchmark of different library-free DIA strategies
(2023-09-10)Abstract Motivation: Proteomics is advancing rapidly and testing and comparing recently published mass spectrometry acquisition and data analysis methods is the best way to keep up with the advances as ... -
Bioinformatic tools for Big Data in Omic studies with application to genomic inversion calling and multiomic data integration
(2020-09)Motivation: The diversity and huge omics data take biology and biomedicine research and application into a big data era. Most of the current statistical analyses required to analyze omic data are not ... -
Bioinformatics Pipeline for Next Generation Sequencing Analysis in Association Studies of Idiopathic Pulmonary Fibrosis
(2015-09)A complete bioinformatics pipeline for Next Generation Sequencing (NGS) analysis has been developed and applied to study the association of called variants with susceptibility in Idiopathic Pulmonary ... -
Bioinformatics tools for enviromental diagnostics
(2021-09)Traditionally, the detection and identification of microorganisms in water samples is done by culture-dependent methods, but these do not allow the detection of all microorganisms. High-throughput ... -
Calculation of polygenic risk scores for common traits and their interaction with exposure to maternal smoking in the HELIX project
(2021-09)Introduction: Complex traits are determined by both genetic and environmental factors, as well as by their interactions (GxE). Maternal smoking during pregnancy is one of the most relevant exposures ... -
Cell compartment isoform expression analysis using long-read transcriptomics
(2023-09-01)Motivation: Alternative splicing, a crucial post-transcriptional process, enhances proteomic diversity without increasing gene numbers, playing pivotal roles in gene regulation, specialization, and ... -
Clopidogrel Pharmacogenetics, resistance to antiplatelet therapy in ischemic stroke by Epigenome Wide Association Study (EWAS).
(2014-03)Clopidogrel is a widely used antiplatelet drug used in preventing vascular events after suffering a first stoke. Genome-wide association studies (GWAS) has not been able to establish a clear association ... -
Codon frequency is modulated by proteic selection, resulting in a coding profile in Archaea and Yeast
(2021-08)Codons as fragments of the genetic code articulate both nucleotidic and proteic constraints. If codon usage bias is now admitted to be mainly influenced by GC content, codon frequencies in general may ... -
Comparative analysis of Microarray and RNAseq data from liver cancer samples
(2017-07-17)Background: The field of transcriptomics has developed an exponential growth in the last years thanks to the advances in high throughput RNA sequencing (RNAseq), which is becoming more popular as the ... -
Computational toolbox towards evolutionary domain mapping of membrane proteins
(2014-01)Membrane proteins account for about 20% to 30% of all proteins encoded in a typical genome. They play central roles in multiple cellular processes mediating the interaction of the cell with its ... -
Copy number variations of colorectal cancer by whole exome sequencing data
(2014-09)Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death worldwide. About 85% of the cases of CRC are known to have chromosomal instability, an allelic ... -
Deep learning for oncological medical image
(2023-09-10)Abstract Background: The emergence of deep learning (DL) in the field of medical imaging has brought significant improvements, especially in pathology and radiology. In pathology, artificial intelligence ...