Listando Màster Universitari en Anàlisi de Dades Òmiques por fecha de publicación
Mostrando ítems 1-20 de 89
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Computational toolbox towards evolutionary domain mapping of membrane proteins
(2014-01)Membrane proteins account for about 20% to 30% of all proteins encoded in a typical genome. They play central roles in multiple cellular processes mediating the interaction of the cell with its ... -
Gene Set Analysis for improving genetic association studies
(2014-01)Introduction. Genetic epidemiology is focused on the study of the genetic causes that determine health and diseases in populations. To achieve this goal a common strategy is to explore differences in ... -
Analysis of the mitochondrial DNA of Schizophrenia patients by next generation sequencing
(2014-01)Mitochondrial DNA (mtDNA), a maternally inherited 16.6-Kb molecule crucial for energy production, is implicated in numerous human traits and disorders. It has been hypothesized that the ... -
Clopidogrel Pharmacogenetics, resistance to antiplatelet therapy in ischemic stroke by Epigenome Wide Association Study (EWAS).
(2014-03)Clopidogrel is a widely used antiplatelet drug used in preventing vascular events after suffering a first stoke. Genome-wide association studies (GWAS) has not been able to establish a clear association ... -
Copy number variations of colorectal cancer by whole exome sequencing data
(2014-09)Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death worldwide. About 85% of the cases of CRC are known to have chromosomal instability, an allelic ... -
Integrating quantitative proteomics and metabolomics in a cellular model of diabetic retinopathy
(2014-09)Diabetic retinopathy is the leading cause of visual loss in individuals under the age of 55. Most investigations into the pathogenesis of diabetic retinopathy have been concentrated on the neural retina ... -
Identification of molecular subtypes and gene expression patterns of breast cancer analysing RNA-seq data
(2014-09)Breast cancer is the most common diagnosed cancer and the leading cause of cancer death among females worldwide. It is considered a highly heterogeneous disease and it must be classified into more ... -
Study of tergal glands morphogenesis through an integrative analysis of genomic data
(2014-09)About 50% of living species are holometabolan insects. Therefore, unraveling the ori- gin of insect metamorphosis from the hemimetabolan (gradual metamorphosis) to the holometabolan (sudden metamorphosis ... -
Finding and characterizing Partially Methylated Domains in human haematopoietic cells
(2014-09)DNA cytosine methylation has been demonstrated to be a central epigenetic modification that has essential roles in a myriad of cellular processes. Some examples of these include gene regulation, DNA-protein ... -
Methylation Data Analysis Associated with Alzheimer’s Disease
(2015-09)Alzheimer disease (AD) is associated with distinctive changes in DNA methylation patterns. DNA methylation is a chemical modification that is involved in gene silencing. These modifications give rise ... -
Identification of chromosomal rearrangements in colorectal cancer
(2015-09)Cancer research is continuously shedding light into these worldwide leading diseases. It is mandatory to have higher knowledge in cancer biology to consequently find out new candidate biomarkers and ... -
Bioinformatics Pipeline for Next Generation Sequencing Analysis in Association Studies of Idiopathic Pulmonary Fibrosis
(2015-09)A complete bioinformatics pipeline for Next Generation Sequencing (NGS) analysis has been developed and applied to study the association of called variants with susceptibility in Idiopathic Pulmonary ... -
Evaluation of the performance of commonly applied global ancestry algorithms in complex spatial demographic scenarios
(2016-09)The development of new methods for inferring ancestral origins in human populations has atracted a renewed interest for human population geneticists for better understanding recent human evolutonary ... -
Association between polymorphic inversions and miRNA in cancer data
(2016-09)Inversion polymorphisms is a mechanism that involves a change in the orientation of a DNA segment within a chromosome, but there is still a lack of their association with disease. However, recently ... -
Gene expression network in PiZZ Alpha1 Antitrypsin Deficiency and its impact on the disease evolution
(2016-09-19)Introduction Chronic obstructive pulmonary disease (COPD) is a complex disease with both genetic and environmental determinants, the most important of which is cigarette smoking. However, genetic ... -
Evolutionary analyses of gene by environment variants associated to body shape in human populations
(2016-09-19)Obesity and body fat distribution is a complex phenotype highly heritable. Genetic variants showing association with BMI, a measure of body size, or waist-to-hip ratio adjusted for BMI (WHRadjBMI ), ... -
Exploring HLA class II allele associations with markers of HIV control
(2016-09-19)Among HIV seropositive individuals, the progression of the HIV-related disease is quite heterogeneous, partially due to the genetic background of the patients. Different host genetic factors have been ... -
Genome-wide DNA methylation association study of predominant breastfeeding
(2016-09-19)Introduction: Breastfeeding is considered a healthy habit with clear benefits at population level. It has been associated with lower risk of infections, asthma, obesity, diabetes or malocclusion, with ... -
Epigenomic data integration for characterization of promoter regions
(2016-09-19)Understanding the regulatory machinery is one of the current challenges for research in cancer epigenomics. Regulation of gene expression is a complex process with many components involved in it such ...