Màster Universitari en Anàlisi de Dades Òmiques: Recent submissions
Now showing items 21-40 of 89
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Employing serial Cox modeling for identification of pan-cancer biphasic genes
(2023-09-10)Abstract Motivation: Some genes, termed 'biphasic genes', can transition between a preventive and promoting effect on disease recurrence during cancer progression. Identifying these genes poses substantial ... -
Deep learning for oncological medical image
(2023-09-10)Abstract Background: The emergence of deep learning (DL) in the field of medical imaging has brought significant improvements, especially in pathology and radiology. In pathology, artificial intelligence ... -
Understanding the effect of ivermectin in non-severe COVID-19 patients through transcriptomics analyses
(2023-09-10)Abstract Motivation: Ivermectin inhibits SARS-CoV-2 replication in vitro at concentrations 35 times higher than approved clinical dosages for humans. This finding prompted numerous randomized clinical ... -
Establishing bioinformatic benchmarks for in vitro engineered thymus from human pluripotent stem cells
(2023-09-01)Advancements in regenerative medicine have facilitated the development of fully human artificial thymic organoids (ATO) derived from human pluripotent stem cells (hPSCs) in vitro. This study presents a ... -
It is possible to extrapolate pathogenicity in mutations in the same position in homologous proteins
(2023-09-10)Abstract When we compare an individual’s genome with the reference, several mutations are encountered. Most of these mutations are neutral, but some others can lead to pathogenic consequences. Given ... -
Oral/Gut microbiome profiles in pancreatic cancer and their interactions with dietary patterns
(2022-09-10)Background and aims: Pancreatic cancer (PC) has a high case-fatality rate in Western countries, expected to rise in coming years if no immediate actions are taken. Several studies have pointed to an ... -
An evaluation of automated methods for cell type annotation in scRNA-seq data
(2022-09)Single-cell RNA sequencing (scRNA-seq) is a powerful new method that makes it possible to study gene expression data at the level of individual cells. Cell type annotation, using a reference sets, is ... -
Omic characterization of melanoma for the identification of potential biomarkers in response to immune checkpoint inhibitors
(Cancer bioinformatics, 2022-08)Cutaneous Malignant Melanoma (CMM) is a rapidly increasing malignancy for which immune check-point inhibition has proved efficient in inducing an anti-cancer immune response. However, not all pa-tients ... -
Developing a CITE-sequencing analysis pipeline by investigating a COVID-19 dataset
(Bioinformatics, 2022, 09–12 doi: 10.1093/bioinformatics/ER, 2022-09-12)Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-sequencing) is a multimodal highthroughput single-cell technology that measures contemporaneously gene and surface protein expression ... -
Refining the genomic landscape of pediatric and young adult aggressive B-cell lymphomas
(2022-09-12)Aggressive B-cell non-Hodgkin lymphomas in children and young adults (CAYA) include the genetically well-defined Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). Additionally, a group ... -
Insights into the transcriptomic effects of olaparib response on a breast cancer preclinical model
(2022-09)In the past decades, many breast cancer treatments have been approved. Although an effort has been done to identify sensitive patients to specific treatments, such as targeted therapies like ... -
A pilot study on extracellular vesicles (EV)s and their small RNA (sRNA) expression pattern in Huntington's Disease progression
(2021-09-15)The characterization of the small transcriptome reveals a generalized down-regulation both at premanifest and manifest stages, which brings out the course of Huntington’s disease. Partial Least Squares ... -
Bioinformatics tools for enviromental diagnostics
(2021-09)Traditionally, the detection and identification of microorganisms in water samples is done by culture-dependent methods, but these do not allow the detection of all microorganisms. High-throughput ... -
Calculation of polygenic risk scores for common traits and their interaction with exposure to maternal smoking in the HELIX project
(2021-09)Introduction: Complex traits are determined by both genetic and environmental factors, as well as by their interactions (GxE). Maternal smoking during pregnancy is one of the most relevant exposures ... -
An unsupervised multi-omics clustering based on ensemble deep learning reveals subgroups of cancer patients
(2021-09)ancer is a complex disease caused by the abnormal behavior and interaction of different bio entities (e.g., genes, proteins and epigenetic factors), which are profiled using omics technologies (e.g., ... -
Unraveling the microglia-oligodendrocyte transcriptomic crosstalk for the identification of myelination biomarkers
(2021-09-14)Background: While there is information on transcriptomic biomarkers of demyelination, the heterogeneity in the methods and cell types/tissues used makes it difficult to select transcriptomic biomarkers ... -
Investigating the Genetic Basis of the Co-occurrence of Irritable Bowel Syndrome and Anxiety
(2021-09-13)Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder representing a serious burden to the healthcare system. IBS research is extremely challenging due to the multifactorial etiology ... -
Evaluating the polygenicity of brain structure features using Compositional Data Analysis
(2021-09-15)Background: Imaging genetics (IG) studies aim to jointly analyse neuroimaging and genetic data with the objective of discovering new genetic variations related to brain features. Most IG studies focus ... -
Codon frequency is modulated by proteic selection, resulting in a coding profile in Archaea and Yeast
(2021-08)Codons as fragments of the genetic code articulate both nucleotidic and proteic constraints. If codon usage bias is now admitted to be mainly influenced by GC content, codon frequencies in general may ... -
Vignette rKOMICS application example
(2021-07-21)The core features of the rKOMICS package include data aggregation, analyses and visualization that allows to examine, summarize and extract meaningful information from minicircle sequence alignments as ...