Màster Universitari en Anàlisi de Dades Òmiques: Recent submissions
Now showing items 61-80 of 89
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Polygenic Risk Score in complex diseases
(2018-09)Motivation: Plenty genome-wide datasets are produced from complex diseases by traditional GWAS studies, but they are limited. A new approach has emerged in the last decade, the Polygenic Risk Scores ... -
Impact of the Nutritional Supplementation with DHA on Cystic Fibrosis Microbiota
(2018-09-27)Cystic fibrosis (CF) is a genetic disease characterized by the formation of thick secretions in the gut and airways, among other anatomical locations, which leads to an altered microbiota. Understanding ... -
Association between polymorphic inversions and miRNA in cancer data
(2016-09)Inversion polymorphisms is a mechanism that involves a change in the orientation of a DNA segment within a chromosome, but there is still a lack of their association with disease. However, recently ... -
Epigenomic data integration for characterization of promoter regions
(2016-09-19)Understanding the regulatory machinery is one of the current challenges for research in cancer epigenomics. Regulation of gene expression is a complex process with many components involved in it such ... -
Evaluation of the performance of commonly applied global ancestry algorithms in complex spatial demographic scenarios
(2016-09)The development of new methods for inferring ancestral origins in human populations has atracted a renewed interest for human population geneticists for better understanding recent human evolutonary ... -
StP: a web server to predict pathogenesis of non-synonymous single nucleotide polymorphisms in membrane proteins
(2017-09-18)Next-generation sequencing has speed up the process of sequencing a complete human genome, while reducing the cost. Consequently its use is increasing in healthcare in order to identify genetic variations ... -
mCSEA: Identification of subtle differential methylation in predefined regions. Studying the epigenomics of fetal growth disorders
(2017-09)DNA methylation is the most studied epigenetic mark. It affects gene expression and has an im-portant role in several disorders. EWAS are performed to find associations between DNA methylation alterations ... -
Determinants of gut microbiota in 7-year old children from INMA birth cohort: a pilot study
(2017-09)Introduction: Gut microbiota plays an important role in humans. Its composition changes from birth to adulthood. Type of delivery, antibiotics use, diet, obesity, and host genetics, among others have ... -
The integration of transcriptome and epigenome in the association of mosaic loss of chromosome Y (mLOY) and cancer
(2017-09-15)It has been demonstrated that mosaic loss of chromosome Y (mLOY) is associated with aging and age-related disease such as cancer [1, 2] or Alzheimer's disease [3]. However, the integrate mechanisms of ... -
Comparative analysis of Microarray and RNAseq data from liver cancer samples
(2017-07-17)Background: The field of transcriptomics has developed an exponential growth in the last years thanks to the advances in high throughput RNA sequencing (RNAseq), which is becoming more popular as the ... -
Functional annotation pipeline for the analisys of microarray data with regards to subcellular protein localization
(2017-09)Subcellular protein localization prediction is a bioinformatics approach (faster and cheaper than experimental procedure) to determine the targeting location of proteins into the cell organelles. ... -
Development of a scoring function for finding differential expression - application to Lolium Perenne
(2017-09)RNA-sequencing for detecting changes between expression patterns has emerged as a frequent tool in life sciences stud- ies. However, it is an under-development tool which still lacks a standard ... -
Evolution of mtDNA variation during canid’s domestication
(2017-09-18)The close coexistence between human beings and dogs and the efficiency in their domestication have made dogs a very interesting target for basic research. By studying the history and evolution of dogs, ... -
Integrative Multidimensional Methods applied to Molecular Classification in Muscle Invasive Bladder Cancer
(2017-09-18)To move toward a molecular taxonomy, we investigated three genome-wide platform data, integrated as an unified categorical code called gene configuration. We performed a multidimensional analysis of ... -
Dissecting the genetic signatures of a multipotent hematopoietic progenitor’s subpopulations
(2017-09-12)In hematopoiesis and other developmental systems, there is an active debate regarding the heterogeneity of apparently phenotypically homogeneous progenitors having different lineage potentials. The ... -
Epigenetic Clock Assessment
(2017-09-18)Background: During the last decade, multiple efforts have been dedicated to the modelling of an accurate predictor of age based on DNA methylation status(1–4). However, most of current models have been ... -
Methylation Data Analysis Associated with Alzheimer’s Disease
(2015-09)Alzheimer disease (AD) is associated with distinctive changes in DNA methylation patterns. DNA methylation is a chemical modification that is involved in gene silencing. These modifications give rise ... -
Identification of chromosomal rearrangements in colorectal cancer
(2015-09)Cancer research is continuously shedding light into these worldwide leading diseases. It is mandatory to have higher knowledge in cancer biology to consequently find out new candidate biomarkers and ... -
Bioinformatics Pipeline for Next Generation Sequencing Analysis in Association Studies of Idiopathic Pulmonary Fibrosis
(2015-09)A complete bioinformatics pipeline for Next Generation Sequencing (NGS) analysis has been developed and applied to study the association of called variants with susceptibility in Idiopathic Pulmonary ... -
Identification of molecular subtypes and gene expression patterns of breast cancer analysing RNA-seq data
(2014-09)Breast cancer is the most common diagnosed cancer and the leading cause of cancer death among females worldwide. It is considered a highly heterogeneous disease and it must be classified into more ...