| dc.contributor | Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia | |
| dc.contributor | Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques | |
| dc.contributor.author | Redondo Guitarte, Ana Belén | |
| dc.date.accessioned | 2022-01-17T09:02:40Z | |
| dc.date.available | 2022-01-17T09:02:40Z | |
| dc.date.created | 2021-09-15 | |
| dc.date.issued | 2021-09-15 | |
| dc.identifier.uri | http://hdl.handle.net/10854/6926 | |
| dc.description | Curs 2020-2021 | es |
| dc.description.abstract | The characterization of the small transcriptome reveals a generalized down-regulation both at premanifest
and manifest stages, which brings out the course of Huntington’s disease. Partial Least Squares Discriminant
Analysis reveals transfer RNA-derived sRNAs (tRFs) as the biotype with stronger discrimination potential,
both at premanifest and manifest stages. Thus, tRFs are targeted as potential biomarkers that would allow
to discriminate early alterations in Huntington’s disease patients. This initial study shows promising results
in a small set of samples that should be replicated in a larger cohort. | es |
| dc.format | application/pdf | es |
| dc.format.extent | 25 p. | es |
| dc.language.iso | eng | es |
| dc.rights | Tots els drets reservats | es |
| dc.subject.other | Corea de Huntington (Malaltia) | es |
| dc.subject.other | RNA | es |
| dc.subject.other | Expressió gènica | es |
| dc.subject.other | Sistema nerviós -- Degeneració | es |
| dc.title | A pilot study on extracellular vesicles (EV)s and their small RNA (sRNA) expression pattern in Huntington's Disease progression | es |
| dc.type | info:eu-repo/semantics/masterThesis | es |
| dc.description.version | Director/a: Josep Maria Serrat | |
| dc.description.version | Supervisor/a: Geòrgia Escaramís Babiano | |
| dc.rights.accessRights | info:eu-repo/semantics/closedAccess | es |
