Màster Universitari en Anàlisi de Dades Òmiques: Envíos recientes
Mostrando ítems 41-60 de 89
-
The impact and function of C-terminal degrons and protein misfolding in the degradation of truncated proteins
(2020-09-15)Premature Termination Codons (PTCs) are mainly generated after nonsense and frameshift alterations. The Nonsense Mediated Decay (NMD) system detects and degrades mRNAs containing PTCs. However, the ... -
Bioinformatic tools for Big Data in Omic studies with application to genomic inversion calling and multiomic data integration
(2020-09)Motivation: The diversity and huge omics data take biology and biomedicine research and application into a big data era. Most of the current statistical analyses required to analyze omic data are not ... -
Determination of immunogenic epitopes
(2020-09-15)The identification of immunogenic epitopes (such as fragments of proteins, in particular peptides, that can trigger an immune response) is a fundamental need for immune-based therapies. A computational ... -
Genetic analysis of the anticoagulant proteins Antithrombin, Protein C and Protein S
(2020-09-15)Cardiovascular diseases (CVDs) are the number one case of dead globally according to the World Health Organisation (WHO) ahead of cancer and respiratory diseases. Most of CVDs are caused by a combination ... -
Telomere length and Alzheimer's disease endophenotypes: a Mendelian Randomization study
(2020-09-15)Background: Telomere length (TL) is a putative biomarker of biological aging and aging-related outcomes. Observational studies are limited to conclude whether TL is causally associated with Alzheimer’s ... -
Development of a machine learning algorithm classification tool to improve strain detection in whole genome metagenomics dataset
(2020-05-15)Metagenomics is a pioneering branch of bioinformatics that utilizes genomics techniques, like the sequencing of the DNA, in order to obtain important information about microorganisms. During the recent ... -
Gene expression network in PiZZ Alpha1 Antitrypsin Deficiency and its impact on the disease evolution
(2016-09-19)Introduction Chronic obstructive pulmonary disease (COPD) is a complex disease with both genetic and environmental determinants, the most important of which is cigarette smoking. However, genetic ... -
Genome-wide DNA methylation association study of predominant breastfeeding
(2016-09-19)Introduction: Breastfeeding is considered a healthy habit with clear benefits at population level. It has been associated with lower risk of infections, asthma, obesity, diabetes or malocclusion, with ... -
Investigation of the Genomic Landscape of Linker Histone 1 Subtypes Uncovers Differences among Variants and a Potential Dual Behaviour of H1X Subtype in Human Cervical Cancer Cells
(2018-09-16)Human cells contain seven somatic histone H1 variants (H1.1 to H1.5, H1.0 and H1X). Although some advances have been recently achieved in the understanding of the H1 subtypes genomic distribution, whether ... -
Identification of Blattella germanica piRNAs
(2018-09)The Piwi-interacting RNA (piRNA) system is an evolutionarily conserved mechanism involved in the control of transposable elements and maintenance of genomic stability, especially in germ line cells ... -
Local assortativity as a chromatin network analysis tool
(2018-09)Using network analysis in the study of chromatin 3D structure has proved to be a powerful and useful approach. In order to determine which factors bound to DNA might play a role in establishing these ... -
Integration of omics and non-omics data in pancreatic cancer research
(2018-09-17)Background: With the wide-spreading in high-throughput technologies and the arrival of omics era, new bioinformatics tools are available for the integration of different data types. Epidemiological and ... -
Exploring HLA class II allele associations with markers of HIV control
(2016-09-19)Among HIV seropositive individuals, the progression of the HIV-related disease is quite heterogeneous, partially due to the genetic background of the patients. Different host genetic factors have been ... -
Evolutionary analyses of gene by environment variants associated to body shape in human populations
(2016-09-19)Obesity and body fat distribution is a complex phenotype highly heritable. Genetic variants showing association with BMI, a measure of body size, or waist-to-hip ratio adjusted for BMI (WHRadjBMI ), ... -
Topological Mapping of genetic variations in human Olfactory Receptors
(2018-09-17)The human olfactory system has enormous discriminatory power, with the ability to detect millions of different odorants. The initial recognition of chemical volatiles is performed by the large family of ... -
A population genomic analysis of genetic markers associated to Twinning susceptibility in humans
(2018-09-17)Spontaneous dizygotic (DZ) twinning is a complex trait with an important contribution from environmental factors and genetic disposition. Twin births is a common event with a worldwide incidence that ... -
Novel transcript discovery in yeast using sequencing reads from Oxford Nanopore Technologies in comparison to Next Generation Sequencing
(2018-09)The advent of Oxford Nanopore Technologies is expected to play a pivotal role in near future sequencing studies. Omics data analysis and related processes, currently bound to Next Generation Sequencing, ... -
Modelling GPCR homodimers using molecular dynamics simulations
(2018-09-17)G protein-coupled receptors (GPCRs) form the largest family of membrane proteins in the human genome and are involved in important physiological functions. Therefore, they are very attractive pharmacological ... -
Machine learning methods in personalized medicine: application to genomic data in Alzheimer's disease
(2018-09)The main goal of this project is to validate and compare machine learning methods to perform GWAS analysis. This study worked with genomic data on Alzheimer’s disease (AD). The data obtained was imputed ...